If he can just handle senior year, scholastic boy wonder Malcolm (Frankie Muniz) may finally get his chance to fly the coop and head off to college in the farewell season of the offbeat Emmy-winning comedy. But in the meantime, he'll have to endure fresh family tortures, including a road trip with the clan to the Burning Man festival, being quarantined with his mom (Jane Kaczmarek) and ending up in the same class as Reese (Justin Berfield).