After vowing to step away from his dark experiments, Dr. Henry Frankenstein (Colin Clive) is blackmailed into creating another fiend (Elsa Lanchester) -- this time, in female form -- who will serve as a ghoulish bride for his infamous monster (Boris Karloff). Ernest Thesiger co-stars as Frankenstein's deranged mentor, Dr. Septimus Pretorius, who forces the doctor's hand by kidnapping his wife (Valerie Hobson).