While escorting four of his patients to a Yankees game, a shrink (Dennis Boutsikaris) gets waylaid by crooked cops, and his quartet of crazies is unleashed on the streets of New York City in this comic gem from director Howard Zieff. Michael Keaton, Christopher Lloyd, Peter Boyle and Stephen Furst deliver first-rate performances as the foursome of lovable loonies who are forced to fend for themselves while banding together to save the doctor.